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For the Purchase Tracker sample application: Add a Purchase class to the business object Class Library project (PTBO) You can create this class from Solution Explorer, as shown in the preceding chapter, or from Class Designer, as detailed earlier in this chapter Set the Purchase class to inherit from the base business object class (PTBOBase) You can define the inheritance in the Code Editor, as shown in the preceding chapter, or from Class Designer, as detailed earlier in this chapter Add class documentation using XML comments Add properties to the Purchase class for PurchaseDate (Nullable(Of Date)), Quantity (integer), ProductID (integer), and CustomerID (integer) You can type the code for these properties in the Code Editor, as shown in the preceding chapter, or add the properties using Class Designer as shown in this chapter or use a property snippet, as shown in this chapter In any case, be sure to include the code to call DataStateChanged in the PurchaseDate and Quantity properties Add a PurchaseID property to the Purchase class The PurchaseID property in the Purchase class is implemented like the ProductID in the Product class:

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During the course of simulation, in order to select the allowed new locations and orientations of particles, we have to examine whether the trial moves lead to overlap of spheroids. The checking of the overlap of spheroids is facilitated by the use of a contact function. The contact function FAB(rA, OA, rB, OB) is defined for a pair of particles A and B centered at r A and rB, and with orientations 0A and OB, respectively. For two ellipsoids A and B, Perram and Wertheim [1985] define a parametric function of the two particles as

(8.5.6)

(8.5.7)

(8.5.8)

Private _PurchaseID As Integer Public Property PurchaseID() As Integer Get Return _PurchaseID End Get

It reviews the social, political, and economic potential of the industry, from developing higher-performance fabrics for the military to developing cures for inborn diseases, to developing techniques, such as cloning, that enable research and development The chapter also provides a glimpse of the best-case scenarios for the industry, as well as the signi cant hurdles that must be overcome for these hopes to become a reality 2 Pharmaceuticals This chapter explores the economics of the biotech pharmaceutical industry Starting with a discussion of established markets, such as bulk enzymes, the speci cs of the pharmaceutical market are described Investment issues, including the rationale for investing in new biotech methods are outlined The role of intellectual property protec tion, mergers, and modifying existing drugs in maintaining growth of large pharmaceutical rms is also considered 3 Medicine and Agriculture.

In (8.5.8), ai is the column vector denoting the direction of the ai vector with the given orientation Oi. Similar definitions apply to bi and Ci. For example (()A, A) = OA, then a~ = [sin()Acos A, sin()A sin A, cos ()A]. Also ai, bi , and Ci are the length of the semi-axis ai, bi' and Ci, respectively. The matrix Gi depends on the shape and orientation of the ellipsoid. G i

and Gi are symmetric and positive definite. The parameter .\ is restricted within the interval 0 ::; >. ::; 1, so that F(r, >') 2:: O. For fixed>., the function F(r,.\) has a unique minimum as a function of r. The contact function FAB(rA, OA, rB, OB) is thus constructed in terms of the object function S(>.).

(8.5.9)

S(.\)

= rr!Jn[F(r, .\)]

Private Set(ByVal value As Integer)

(8.5.10)

values if A and B overlap if A and B are externally tangent just touching each other if A and B are not overlapping

(8.5.11)